The stressors could be environmental, behavioral or psychological. The reaction to stress could be influenced by the genetics and also by someone’s perception. About 80% of affections could be induced or aggravated by stress. Selye defined stress and described the physiologic changes induced by stress, under the designation “general adaptation syndrome”. The stress means an abnormal or extreme physiological adjustment to the adverse effects of the environment. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.The state of health represents the balance between the mental, emotional, physical and relational areas. After the theoretical part of this article, some selected skin diseases are discussed in more detail from the psychosomatic point of view. Based on the modern psychodermatology concept, other corresponding sub-areas such as psychogastroenterology, psychocardiology etc. The life course belongs also to modern psychodermatological approaches. The "visibility" of the skin organ bestows dermatology a special position among the various other clinical subjects, and renders a holistic, psychosomatic approach to the patient that is particularly important. A holistic approach by the physician should do justice to this interdependence biological, psychological and social factors should be adequately taken into account when taking anamnesis, making a diagnosis and choosing a therapy. These connections are reflected in many skin diseases where psychological and somatic etiological factors are closely intertwined. Recent research shows close anatomical, physiological and functional connections between skin and nervous system, already known to be ontogenetically related. It is nowadays experimentally proven that "emotions get into the skin". Modern psychodermatology relies on the bio-psycho-social disease model in psychosomatics, according to which biological, psychological and social factors (on various levels, from molecules to the biosphere) play a major role in the disease pathogenesis through complex, non-linear interactions over the entire disease course.
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